For my friends and I who love comics this show is breath of fresh air. A bunch of loser villains that you actually root for to actually accomplish something. In many ways this show reminds me of Married With Children with Supervillains, Voltar the leader the Al Bundy of evil.
Every time I have seen this show I am laughing hard. I normally hate Cartoon Network cartoons LOSE is one of two cartoons I like on the show. Clone Wars is the other.