Psychologist Dr. Kate McGinn and her partner, former detective Price Whatley, attempt to help Noah, a teen suffering from regression episodes - repressed memories from a past life - in which Noah remembers a previous life's kidnapping and murder. Together with Dr. Malachi Talmadge and Dr. Rishi Karna, McGinn and Whatley work to track down the perpetrator of a crime committed 14 years earlier.
The team meets Corrine, a young woman dealing with addiction whose regression episodes include graphic details of a violent crime scene. Meanwhile, Kate and Price travel to Florida in hopes of uncovering Corrine's role in the crime, which could also help save an innocent death row inmate from execution.
When two people share the same flashbacks/regressive episodes, Kate, Price, Malachi and Rishi discover the couple are star-crossed lovers who rediscover each other in each life, and the team must go to great lengths to keep the pair from fulfilling a destructive pattern.
When a young girl exhibits physical manifestations from traumatic past-life memories, she is dubbed a saint by the media and is brought to the team's attention. From saint to sinner, the "Saint" Sarah case leads Kate and Price to a serial killer.
When an office worker with no previous psychiatric history is accused of stealing, he erupts in a violent outburst, forcing his co-workers to call in the Talmadge team. Kate and Price travel with their patient to Texas only to discover he was involved in a violent crime in a past life.
When a wealthy hotelier has a near-death experience, his soul makes contact with a recently deceased young man. The encounter leaves him with imprinted with someone else's memories, forcing the team to track down the young man's identity.