When Detective Loki is speeding to the hospital at the end, he passes the same restaurant (with a red awning) three times: once as he pulls off the smaller road onto the major road, and twice after that.
When Loki leaves Keller's house and is sitting in his car about to leave, he has a toothpick in his mouth. Keller runs out of the house to speak to him and Loki curses, opens the car window and talks to Keller while still chewing the toothpick. In the very next scene showing Loki in the car, the toothpick is gone.
When Detective Loki goes to question Bob Taylor at his home (the house with the snakes), the mailbox pole by the driveway shows the address number as "4261" but when Loki calls for backup he gives the address as "427 Carol Street".
The area code on Dover's truck is 570, which is the Scranton/Wilkes Barre area of Pennsylvania, but the license plate on Loki's car indicate Montgomery County, which is a couple of hours south and does not use the 570 area code.
Detective Loki works for a municipal police department in Pennsylvania yet all of the police cars with lights activated have only blue lights. Blue lights in Pennsylvania are "courtesy lights" for volunteer firefighters/EMS personnel private vehicles. They are not emergency lights with any traffic control powers. Police use either a combination of red and blue or, if using a single light, red only.
When Keller is deer hunting with his son, the two families are celebrating Thanksgiving. The film takes place in Pennsylvania, where deer hunting season does not begin until the first Monday after Thanksgiving.
The goof item below may give away important plot points.
Incorrectly regarded as goofs
Possible plot hole: how did Keller Dover find his daughter's missing red whistle in the pit beneath the Trans Am? if she had only just lost it before the Thanksgiving party which was before she was even kidnapped? It would have gotten there before she even reports she lost it?Chronologically impossible. It is explained in the movie, that both girls found it before the kidnapping. The kidnapper hide the girls down there when the police showed up and the girl must have lost it then.