Each segment features Joe with his legs fully functional - only to end up paralyzed somehow during each story making this episode the second, third and fourth time Joe walks.
Roy Scheider's final television appearance as well as his second and final Family Guy appearance. This episode aired a year after his death in February 2008.
The scene where Stewie shoots the police officer in the face in Misery story was cut from Germany.
The Stand By Me segment makes reference to the real-life fates of two cast members. We are told that Cleve, the fat kid, grew up to marry Rebecca Romijn, just as Jerry O'Connell did. We are also told that Quag died of a drug overdose outside the Viper Room, a reference to the real-life death of River Phoenix.
During the "Misery" segment, Brian accidentally hits Stephen King with his car (which was loosely based on a real life incident). In an earlier FG episode, there was a cutaway joke where Brian hit someone with his car, asking if it was Stephen King. When finding out that it was Dean Koontz, Brian proceeded to back over him.