In the season premiere, which takes place five years after last season's climax, Owen has to reintegrate into normal life at the hospital after spending time in prison. KEEGAN-MICHAEL KEY (Key and Peele, MADtv) guest stars.
Blake asks Glenn to coach him through a new romantic relationship. Chief and Cat prank call Sy. Guest stars include Lindsay Sloane, James Adomian, Paul Scheer, Nick Offerman, Jordan Peele and Brian Huskey.
When a newspaper calls Glenn a "rock star surgeon," he worries that he'll die on his upcoming 27th birthday, like so many of his fellow rock stars before him. Meanwhile, Chief opts for a "staycation" at the hospital.
Glenn returns to the Lower East Side of São Paolo, Brazil, for his family's weekly Shabbat dinner. Guest stars include Ben Feldman, Mimi Kennedy, Michael Lerner, Lindsey Kraft, David Wain, Seth Morris, Jamie Denbo and Zandy Hartig.