Universal Soldier: Regeneration
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Yes. "Universal Soldier: Regeneration" (2009) has retconned "The Return" to the point none of the events of the movie ever happened in the main Universal Soldier continuity. "The Return" is now a self-contained alternate universe.

- For instance, in "Regeneration" it is strongly hinted that Luc Deveraux never reverted to the "human" state, nor such process is ever possible to accomplish.

- In "Regeneration" it is apparent Luc never had a daughter as once depicted in "The Return", nor he seems able to psychologically adjust to human life again and mate as a "normal" people.

- Even more importantly, in "Regeneration" it is officially stated that the N.G.U. project ("The White Tower") is just the second attempt at producing UniSols, not the third one.

- Finally, you can notice in "The Return" Luc displays white/gray streaks in his hair that are nowhere to be seen in "Regeneration".

Generally speaking, "Regeneration" totally ignores "The Return" and even contradicts it.

Yes, but it is implied in the movie that this is a clone of Andrew Scott, not the original person. When the container he is being transported in is opened, the scientist says, "We've come a long way from regenerating sheep."

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