In this episode, Meredith says "That's one of us down there, show some respect" which is an allusion to when she said the same thing on the first episode about George during his surgery.
When Lexie is undressing, they do not show her bare back. This is due to a large lower back tattoo the Chyler Leigh has. They continue to avoid her bare back throughout her time on the show.
Christa B. Allen is supposed to be 16 and the older sister of the character Kay Panabaker plays. Kay Panabaker was 17 or 18 when she was supposed to be 15 and Christa B. Allen was 16, her characters age. Kay Panabaker is a year older than Christa B. Allen, who is supposed to be her character's older sister.
Kay Panabaker and Christa B. Allen both appeared in two different episodes of Medium (2005) but involving the same villain, played by Mark Sheppard. Kay Panabaker was in "Penny for Your Thoughts", in which her character was being taken over by the spirit of Charles Walker. In a later episode, "Blood Relations", the past is shown where Christa B. Allen is playing the pregnant wife of Charles Walker. Both actresses also appeared in different episodes of CSI: Crime Scene Investigation (2000) but with no related storyline.