Jennifer Lawrence recommended Bradley Cooper for the project. They had worked together previously on Silver Linings Playbook (2012) and they got along so well that they often spoke about working together again in the future. When Lawrence read the script for Serena (2014), she sent a copy to Cooper and asked if he would do it with her.
According to the director, the post-production of the film was complicated by the need for dialogue dubbing due to airplane noise during the shoot in Prague. Jennifer Lawrence was unable to show up for dubbing sessions. The producers of Serena tried to buy Lawrence out of filming The Hunger Games: Catching Fire (2013) for one day, but that proved to be more expensive than the budget of Serena itself.