The character of Jessica Stevens in the Segment "Rottentail" was played by Ashley Bank from The Monster Squad (1987). She was a last minute replacement and had less then 24 hours to prepare for the role.
Filming on Monsterpiece Theatre was completed when "Rottentail" was wrapped, however the run time was shorter then the producers had wanted on the entire series. So Ethan Terra decided to put "Moonlighting" into production with 10 days of prep.
Ethan Terra decided that the original animatronic puppet creature created for the final kill scene in "The Babysitter" didn't give enough impact, so the producers decided to have him re-shoot the ending with a live actor in full prosthetics.
Ethan Terra had to donate his personal home for filming of "The Weed", because none of the owners in any of the locations that were scouted would allow the producers to dig the 12 foot hole necessary to pull John Carl Buechler's character (Dan The Weed Man) underground for his death scene.
The film uses no CGI, Ethan Terra wanted all the gags to be practical like the ones he grew up with. So all the practical special makeup effects were built by hand by Magical Media Industries and Midnight Studios.