In the scene where Jane answers a phone call from her daughter Lauren, she is clearly surprised by Jake who kisses her causing her to say "You're still on the phone" instead of "You're still on the plane." This was a genuine reaction from Meryl Streep who did not expect Alec Baldwin to kiss her. Nancy Meyers had directed Alec to kiss Meryl since it would be something Jake would do. Fortunately, Streep kept the scene going and incorporated her mistake therefore the scene could be kept in the movie.
Meryl Streep had asked her alma mater, Vassar College, if they could film the college graduation scenes on their campus. They refused even though Streep serves on their Board of Trustees and two of her children attend there.
Although they have never previously worked together in a film, Steve Martin and Alec Baldwin are tied for most times hosting Saturday Night Live (1975) with 14 times each. They also co-hosted the 2010 Academy Awards.