Paramount Pictures originally announced that this film would be their last to be released on 35mm film in the United States and Canada. They later reversed that policy for a few films, such as Transformers: Age of Extinction (2014) and Interstellar (2014).
When Ron and Veronica are called in to Mack Tannen's (Harrison Ford) office at the start of the film, Tannen comes face to face with Veronica and moves her hair. Ron then says "You like-a da merchandise, ehh?", quoting a line from Watto in Star Wars: Episode I - The Phantom Menace (1999). Harrison Ford played Han Solo in Star Wars Episodes IV through VII.
(At around forty-five minutes) When Champ (David Koechner) is showing baseball highlights and yelling "Whammy!" repeatedly, all of the scenes are of the West Michigan White Caps baseball team from Grand Rapids, Michigan.
Jim Carrey, Marion Cotillard, and Liam Neeson all starred in Batman movies. Carrey starred in Batman Forever (1995). Neeson starred in Batman Begins (2005) and The Dark Knight Rises (2012). Cotillard also starred in The Dark Knight Rises (2012).
In the final battle, even though a lot of special cameos don't share a scene together, it marks a reunion of Jim Carrey and Liam Neeson. Both of them appeared in The Dead Pool (1988), the last of the Dirty Harry franchise.
After Mack Tannen turns into a werewolf, one of the brawlers says he now has an idea for a music video and suggests calling Michael Jackson. The music video in question would be Michael Jackson: Thriller (1983).