When interviewing the victim's husband in his office at the studio, Grissom and Brass pick up an award and the husband says for them to be careful with it as it's an Emmy. Grissom says, "Is that what this is?!"; this is a reference to the show being nominated three years in a row for an Emmy and not winning.
The initial premise of this episode, with the difficult-to-work-with titular star, and supporting actress who outshines her, is supposed to mirror "Cybil" and Cybill Shepherd. Chuck Lorre, who wrote this episode, was the creator of "Cybil", and there were well known issues between him and Cybill Shepherd.