When asked about the possibility of a sequel to this film, star Chris Pine replied: "No. I don't think it made enough money for that to happen. That's one of my deep regrets, that we didn't totally get that right. It's a great franchise and if it's not me, then I hope it gets a fifth life at this point. It's just great. I love the spy genre. I hope it's done again and with a great story."
The original screenplay written by Adam Cozad was entitled "Dubai" and was intended to be an action film starring Eric Bana. Paramount later asked Cozad to rewrite his old script and to change the lead character to Jack Ryan.
The painting in Cherevin's office is Bogdan Willewalde's "Czar's Guard Captures 4th Line Regiment's Standard at Austerlitz." The Battle of Austerlitz was a victory for Napoleon and the engagement depicted in the painting was the only major Allied success in the battle. Ryan later alludes to the painting and wrongly connects it to the Battle of Waterloo, where Napoleon used cannon fire to distract attention from his attack. Unlike Austerlitz, Waterloo ended in Napoleon's defeat.