Ezio Auditore da Firenze loosely translates to "like an eagle, auditor of/from Firenze". Auditor derives from the family profession in banking; Firenze is the Italian version of Florence, Ezio's birthplace.
This marks the sixth of seven games that Jesper Kyd has made music for in which the main protagonist is an assassin. The first four being the Hitman series and the last three being the Assassin's Creed series.
The trivia items below may give away important plot points.
In one of "The Truth" puzzles that Ezio unlocks in Florence, there are pictures of world leaders throughout History who are holding the Apple; a piece of EDEN that helped establish their power base. George Washington was one of the leaders pictured. In Assassins Creed 3, there is a sequence where the main character Ratohnhaké:ton experiences an alternate reality where George Washington becomes corrupted by the apple, turning into the "Tyrant King."