The leak of a dangerous virus at a bio-research facility results in the death of a scientist, and Lisbon and Jane clash with a Disease Control official when they decide to treat the death as a homicide.
Patrick is forced to turn to a woman with amnesia to help solve a murder case on an Indian reservation, while special agent Hightower delivers an ultimatum to Rigsby and Van Pelt about their personal relationship.
Patrick's reckless behavior catches up with him when his actions get a case against a hitman thrown out of court and Lisbon on suspension. But when the hitman his shot and killed, he has a shot at redemption.
A man is murdered right before he is to deliver an important speech about human trafficking at a conference. Psychic Kristina Frye is brought in to help CBI solve the case, even though Patrick remains skeptical about her "gift."
The tension between Patrick and Kristina escalates when a Red John impostor strikes and Kristina offers her services to the CBI. However, the case causes the real Red John to come back and meet Patrick for the first time face-to-face.
While CBI discovers that a homicide investigation leads back to Bret Stiles and his "Visualize" cult, Patrick receives a tip that provides proof that Red John has abducted Kristina Frye and that she is probably still alive.