The High School Musical sequel claimed the night's Favorite Movie prize and the film's star, Vanessa Hudgens, took home the Favorite Movie Actress honour. Meanwhile, a shocked Cyrus sobbed through her Favorite Female Singer acceptance speech and her ex-boyfriend, Nick Jonas, and his brothers picked up the Favorite Music Group award.
Other big winners at UCLA's Pauley Pavilion included Selena Gomez (Favorite TV Actress), iCarly (Favorite TV Show), Will Smith (Favorite Movie Actor) and Madagascar: Escape 2 Africa (Favorite Animated Movie).
A bronzed Leonardo DiCaprio also took home the Kids' Choice Awards' inaugural Big Green Help award for his environmental efforts.
And the Kids' Choice Awards wouldn't be the Kids' Choice Awards without plenty of green slime - Favourite Male Singer prizewinner Jesse McCartney got splattered while chatting to show host Dwayne Johnson and funnyman Will Ferrell threw himself down a slime-filled slip 'n' slide on the UCLA campus.
Hugh Jackman and Sandra Bullock were also showered with the green gunk when they opened a briefcase to reveal the winner of the Favorite Book award (Twilight series).
Other highlights included performances from the Pussycat Dolls and the Jonas Brothers, and host Johnson dressing up to look like Cyrus.
More than 90 million online votes were cast for the event - a new record.
The full list of winners:
Favorite Movie - High School Musical 3: Senior Year
Favorite Animated Movie - Madagascar: Escape 2 Africa
Favorite Voice from an Animated Movie - Jack Black (Kung Fu Panda)
Favorite Male Movie Star - Will Smith
Favorite Female Movie Star - Vanessa Hudgens
Favorite TV Show - iCarly
Favorite Reality Show - American Idol
Favorite Cartoon - SpongeBob SquarePants
Favorite TV Actress - Selena Gomez (Wizards of Waverly Place)
Favorite TV Actor - Dylan Sprouse (The Suite Life of Zack and Cody)
Favorite Song - Single Ladies (Put a Ring On It) by Beyonce
Favorite Music Group - Jonas Brothers
Favorite Male Singer - Jesse McCartney
Favorite Female Singer - Miley Cyrus
Favorite Male Athlete - Peyton Manning
Favorite Female Athlete - Candace Parker
Big Green Help Award - Leonardo DiCaprio
Favorite Video Game - Guitar Hero World Tour
Favorite Book - Twilight series