Instead of recording voice-overs in booths, with every actor isolated from everyone else, most of the voice-over work was recorded on a set, with the actors voicing their characters while performing with their fellow cast members. This enabled the performers to follow the rhythms of their co-stars while also giving them room for improvisation.
Clint Eastwood is the visual inspiration for Spirit of the West. In the back of his golf cart, the "Spirit" has five Oscar-like film awards (which Rango calls "golden guardians"). Eastwood has received exactly five Oscars, including his Irving J. Thalberg Award. The voice of the "Spirit," Timothy Olyphant, starred in the Western TV series, Deadwood (2004).
At the poker table in the saloon when Rango first enters, there is an owl in a top hat holding a pair of black aces and a pair of black eights. These were the cards held by notorious Wild West gunman "Wild" Bill Hickok, the moment he was shot dead in a saloon in Deadwood, South Dakota. Bill's hand is since known as "The Dead Man's Hand".
The bottle in which Rango goes into to escape the bird in the desert is called "Jarrito", spanish for a small jar or container, pronounced "har EE toe". When he escapes the bird again in the town, Rango ducks into a latrine made from an empty Pepto-Bismol bottle (an anti-diarrhea medicine).
During the scene in which Rango describes the Spirit of the West to the townspeople by drawing images in the sky with a smoldering stick, it is possible to spot the logo of American rock band KISS, Imperial Tie Starfighters from Star Wars IV, a shark fin, a dinosaur and a "Kilroy was here" drawing for a brief moment.