Jackie realizes she needs professional help, while All Saints is taken over by a corporation whose new director makes a shocking personnel change. Kevin does not react well when he learns the truth about Jackie and Eddie.
Jackie covers for Cruz when he has a panic attack. Zoey surveys her coworkers for the best way to conduct a breakup. Akalitus enlists the staff in an elaborate charade when her mentor enters the hospital, suffering from dementia.
The firing of her colleagues, Grace's refusal to go to school, and an overflowing emergency room full of patients redirected from another hospital push Jackie to finally seize control of the E.R. and run it her way.