When Shawn is running around the museum and Gus is tracking him, the woman that Shawn tries to sneak out behind (when Gus says "Leave that poor woman alone") is played by Dulé Hill's mother.
When Gus is telling Shawn that watching him sneak through the museum is like "watching Entrapment, but instead of watching Catherine Zeta-Jones, they have some guy with pancake butt," the man walking past Shawn is writer/executive producer Steve Franks.
Toward the end of the episode "65 Million Years Off," Shawn says he is going to name the dinosaur he uncovers "Zippy," after he unearths it. It is revealed in this episode that the dinosaur is indeed named Zippy.
First episode to show any depiction of Shawn's mother
When Shawn asks Gus, "Facts and logic are in the corner of the guy who thinks he's going to get his face melted off?", a brief snippet from the Raiders of the Lost Ark (1981) soundtrack can be heard.