Both Seth Green (Ezekiel) and Katrina Bowden (Ms. Tasty) have appeared in Fall Out Boy music videos before this film. Seth Green is in the funeral scene of in "It Ain't a Scene, It's an Arms Race" and Katrina Bowden was the mean girl dancing with Patrick Stump in "Dance Dance".
Director Sean Anders' younger sister, Andrea Anders, plays the trashy trailer park shopgirl who tries to defecate on Clark Duke. Sean Anders didn't find directing his sister too easy as she was half naked most of the time and their mother was on set for most of the filming.
There is a surprising amount of special effects work in the film, necessitated by the fact that it was shot in Florida. Most of these special effects involved the removal of palm trees in the backgrounds.
The song "Got You (Where I Want You)" by The Flys is featured early on in the movie, which was the theme song to Disturbing Behavior (1998). James Marsden was the star of that movie and plays a supporting role in this movie.