Pete and Claudia reunite with Warehouse alum Hugo (Rene Auberjonois) to track down a deadly artifact at his nephew's prep school, while Myka and Steve investigate an Artifact that is killing an up and coming musician (Sam Huntington) in New Orleans.
Pete and Myka investigate a hockey player who seems to be miraculously and instantly recovering from serious game injuries, while Claudia is invited to a mysterious lunch by Mrs. Frederic. Elsewhere, Artie and Steve discover someone has been stealing artifacts from inside the Warehouse. Guest stars BSG actor Mike Dopud as Hockey Player "Mike Madden."
Someone has stolen Lewis Carroll's Mirror from inside the Warehouse allowing the psychotic and murderous spirit of Alice Liddell to escape again. Our team must stop her killing spree before one of them ends up dead. Guest stars Lindsay Wagner as recurring character "Dr. Vanessa Calder."
Pete, Myka, and Claudia each travel to save a loved one who has fallen victim to an artifact, Mrs. Frederic and Steve head to the Vatican to investigate the Brotherhood, and Artie has an impossible showdown with Brother Adrian.
The team tracks an evil alchemist who has bronzed Claudia and stolen the only artifact that can reverse the process. The clock is ticking as Claudia's condition apparently affects both Mrs. Frederic and the Warehouse.
The evil alchemist Paracelsus is on the run, and Pete and Myka must stop him before he achieves immortality - or something worse. Myka fights what appears to be a losing battle against cancer, while Steve learns Artie's been keeping life-altering information from Claudia.