MacPherson escapes with what he took from the warehouse's bronze sector, and a car crash puts Mrs. Frederic in the hospital. Meanwhile Pete and Myka head London to gather clues about MacPherson's plan.
Myka and Pete go to Detroit after a seemingly invulnerable vigilante begins using extraordinary means to thwart criminals. Meanwhile, the rest of the team tries to get past recent events while improving conditions at the warehouse.
For the first time, residents of "Univille" (Warehouse 13's hometown) begin experiencing bizarre and increasingly powerful events leading to the discovery that a dangerous artifact is loose in their own backyard.
Douglas Fargo of Eureka's Global Dynamics is sent to Warehouse 13 to help update its aging computer system. This triggers a seemingly sentient computer virus that sends the Warehouse into lockdown and traps the team inside.
Claudia gets some on the job training in her first field assignment with Myka. But she's a bit overwhelmed by the hunky guys on the wrestling team they're investigating despite their tendency toward spontaneous human combustion. Fortunatly H. G. Wells lends a hand seeking a sympathetic if skeptical ear from Myka. Poor Pete, stuck back at the warehouse, helps Artie with his infatuation with the warehouse doctor and then takes action on his own infatuation.
Wells' treacherous attack and devastating betrayal in Egypt has set into motion the plan she has been secretly orchestrating for more than one hundred years. When it becomes clear that Wells has her hands on the original weapon of mass destruction, Artie, Claudia and Mrs. Frederic race against the clock to stop her deadly endgame.