Warehouse 13 has been destroyed, Pandora's Box has been opened, and quite possibly the only hope left in the world lies in the use of a dangerous, evil artifact with the ability to turn back time.
Pete, Myka, and Claudia each travel to save a loved one who has fallen victim to an artifact, Mrs. Frederic and Steve head to the Vatican to investigate the Brotherhood, and Artie has an impossible showdown with Brother Adrian.