The title card "To be continued in space..." was placed in the movie as a complete joke, with no intention of any sequels. Nonetheless, a sequel, ThanksKilling 3 (2012), was released three years later.
While writing the script, and even through filming, creators Kevin Stewart and Jordan Downey always tried to come up with a name for the killer turkey, but nothing ever stuck. In the end, they simply referred to him as "turkey" in the film. In 2012 while raising funds for the sequel, they again wanted to find a proper name for the character. They finally settled on simply "Turkie".
The opening scene was originally written and planned to be much more extravagant involving an entire Native American and Pilgrim dinner scene. Time and money quickly ran out and the scene was never shot.