Leonard, Howard and Raj fight over Sheldon's twin sister when she arrives in town. Raj takes part in a drug trial to suppress his selective mutism.

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The guys are surprised to see a beautiful young woman in Sheldon's office. They are even more surprised when they learn that she is Sheldon's fraternal twin sister, Missy Cooper, who is in town only for two days to attend a friend's wedding. Against Sheldon's wishes, Leonard invites her to stay with them, which she accepts. Leonard, Howard and even Raj (who is participating in a pharmaceutical study, which includes testing a new drug to overcome extreme shyness) fawn over Missy. Using the argument of potential genius offspring, Leonard convinces Sheldon, who abhors physical and emotional contact even with family, that he needs to act brotherly in looking out for Missy's best interests when it comes to finding a suitable boyfriend. Who better in that role than his roommate. Ultimately, the guys come to a solution on who should pursue Missy. But what will Missy have to say about their choice? Written by Huggo

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Comedy

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5 May 2008 (USA)  »

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16:9
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Did You Know?

Trivia

Howard's belt buckle is The Flash. See more »

Goofs

Sheldon tells his sister that he is a "superior genetic mutation, an improvement on the existing mediocre stock", but that residing within his sister's genes are the potential for another Sheldon. If this is the case, only he would have the mutation that makes him superior and not his sister. Since she is among the mediocre stock, the probability of her having a child with Sheldon's mutation would be no greater than for anyone else. (There is also no evidence that he has any genetic abnormalities.) See more »

Quotes

Raj Koothrappali: Everyone knows genetic diversity produces the strongest offspring. Why not put a little mocha in your latte?
Sheldon Cooper: That is true, but consider the fact that you require medication to even talk to someone of the opposite sex.
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Crazy Credits

In the opening scroll of the time line when it gets to 91,000 there is a mistake the dates read 93,000BC 92,000BC 91,0009C 90,000BC for some reason 91,000 is a 9c not a BC. See more »

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Features Wii Sports (2006) See more »

Soundtracks

Big Bang Theory Theme
Composed and Performed by Barenaked Ladies
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User Reviews

 
The Shiksa Indeterminacy was another great episode of "The Big Bang Theory"
8 May 2008 | by (Baton Rouge, La.) – See all my reviews

Leonard and Raj are looking at an item on the school bulletin board that mentions an experiment that helps someone to basically overcome shyness. Just then, Howard mentions a hot girl in Sheldon's office as Raj and Leonard look in. Turns out she's "Shelly's" twin sister, Missy (Courtney Henggeler). As Sheldon introduces his friends to her, Raj runs off with the board item. Missy's on her way to a friend's wedding, which is the next day, in Anaheim and intends to go there as soon as her business with her brother is done. Leonard offers her to stay at his and Sheldon's place instead which she accepts. Over there, Howard and a suddenly confident Raj make her a little uncomfortable with their comments. At this point, Penny comes in and takes a relieved Missy for some nail polishing. Leonard, seeing this, tells her brother since he's now the man in his family (Sheldon and Missy's father having died long ago), he should look out for his sister. So Sheldon tells his friends how none of them are good for Missy especially Leonard because of his flatulent problem. When Sheldon tells his roommate he can sleep with his sister if he stops farting at certain points, Penny and Missy come back at this point with Missy giving her brother a talking to. Sheldon comes out of his bedroom with his hand over his balls declaring his sister can date anyone she wants. First Leonard, then Howard are shot down for a date with her. When Raj comes to Penny's apartment for Missy, the confidence serum he had on wears off so when the Fine Tall Woman comes to him, Raj can do nothing but squeal! As she starts to leave, Missy tells her brother how she tells people he's a rocket scientist. That chagrins Sheldon since he doesn't think of himself as that at all but something else complicated that I can't think of right now...This was another hilarious episode of "The Big Bang Theory" that fired on all cylinders! Ms. Henggeler was perfectly cast as "Shelly's" twin sister and with her looks really was hot! The obviously fake Southern accent was a little distracting but otherwise she was fine. Howard and especially Raj's exchanges with her were so funny that I crack up just thinking of them! This was one of the best episodes of "The Big Bang Theory" yet! As always, you rock, Chuck Lorre!


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