This is the first episode in which Comic Con (International) is mentioned. Howard says "Every year at Comic Con." in answer to Sheldon posing the question "How often does one see a beloved fictional character come to life?"
The gang talk briefly about the TV show 'Scrubs'. Jim Parsons who plays Sheldon Cooper in the show worked with Zach Braff who played the character of Dr. John 'J.D.' Dorian in the show Scrubs in the film 'Garden State' which was written by and featured Zach Braff.