After the initial argument in the beginning of the episode between Spencer and Grandpa Shay (after Carly, Sam and Freddy leave for the Groovy Smoothie), Grandpa Shay tells Spencer that he'll be staying in the nearby "Parker-Nichols Hotel" for the next couple of days. This is a reference to
Drake & Josh (2004), the TV show in which
Miranda Cosgrove played in alongside stars
Drake Bell (Drake Parker in the show) and 'Josh Peck' (Josh Nichols in the show) this is the first reference to Drake & Josh on the show.