It's the late 1970's, and Crypto faces a conspiracy so vast that even Pox can't help him now.
3 nominations. See more awards »


1 video »


Cast overview, first billed only:
Cryptosporidium / Jack Trippleson (voice)
Orthopox (voice) (as Richard Horvitz)
Darryl Kurylo ...
The Master (voice)
C. Curt Calvin (voice)
Veronica Stone (voice)
Saxon (voice)
The Librarian / Monks (voice)
S. Scott Bullock ...
Vinnie Molinari / Producer (voice) (as Scott Bullock)
Belleville Females / Sunnywood Police Radio (voice)
Legg Tallman / Deep Navel (voice)
Rollo / Sunnywood Bouncer (voice)
Emperor Meningitis / Murray (voice)
Endometriosis / British Sailor (voice)
Jonelle Kennedy ...
Sunnywood Police Radio (voice)
Brad Abrell ...
Heliobacter / American Military (voice)


It's the late 1970's, and Crypto faces a conspiracy so vast that even Pox can't help him now.

Plot Summary | Add Synopsis


Burn, baby, burn!


Action | Comedy | Sci-Fi


T | See all certifications »

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Release Date:

1 December 2008 (USA)  »

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Did You Know?


The Nero hotel is a reference to robert Denero who was in Casino See more »


[first lines]
The Master: The time is nearly at hand. A great wrong will be righted. An ancient prophecy fulfilled... and a hero of legend will arise.
See more »


Follows Destroy All Humans! 2 (2006) See more »


You Got Me, Hun
Based on "I Got You, Babe"
Written by Sonny Bono
Performed by J. Grant Albrecht and Kate Higgins
See more »

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User Reviews

Furon Boogie...
5 March 2009 | by (United Kingdom) – See all my reviews

After twenty years of harvesting brain stems, Cryptosporidium 139 and his bodiless commander Orthopox are living a cushy existence in the Space Dust Casino Los Paradiso. That is, until their lives are turned upside down by an attack from the Molinari brothers, sending on the them on an adventure involving the secret art of kung-fu, a raid on the Louvre and synthetic Furon DNA made mostly of peanut butter...

Yes, after two titles, Destroying All Humans isn't as fresh as it once was. However, the weapons, abilities and story are fresher than ever, with Seventies pop culture references thrown in at every turn. (Who ever imagined vaporising Frenchmen whilst listening to the YMCA? True, the game is quite short and simple (the final boss came all to soon), but the graphics are brilliant, the dialogue is hilarious (particularly between Pox and Crypto, the ever excellent Richard Horvitz and Grant Albrecht) and the game-play is immensely fun while it lasts.

Buy this game!

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