It's the late 1970's, and Crypto faces a conspiracy so vast that even Pox can't help him now.
3 nominations. See more awards »


1 video »


Cast overview, first billed only:
Cryptosporidium / Jack Trippleson (voice)
Orthopox (voice) (as Richard Horvitz)
Darryl Kurylo ...
The Master (voice)
C. Curt Calvin (voice)
Veronica Stone (voice)
Saxon (voice)
Dave Wittenberg ...
The Librarian / Monks (voice)
S. Scott Bullock ...
Vinnie Molinari / Producer (voice) (as Scott Bullock)
Belleville Females / Sunnywood Police Radio (voice)
Legg Tallman / Deep Navel (voice)
Rollo / Sunnywood Bouncer (voice)
Emperor Meningitis / Murray (voice)
Endometriosis / British Sailor (voice)
Jonelle Kennedy ...
Sunnywood Police Radio (voice)
Brad Abrell ...
Heliobacter / American Military (voice)


It's the late 1970's, and Crypto faces a conspiracy so vast that even Pox can't help him now.

Plot Summary | Add Synopsis


Burn, baby, burn!


Action | Comedy | Sci-Fi


T | See all certifications »

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Release Date:

1 December 2008 (USA)  »

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Did You Know?


The Nero hotel is a reference to robert Denero who was in Casino See more »


[first lines]
The Master: The time is nearly at hand. A great wrong will be righted. An ancient prophecy fulfilled... and a hero of legend will arise.
See more »


Follows Destroy All Humans: Big Willy Unleashed (2008) See more »


You Got Me, Hun
Based on "I Got You, Babe"
Written by Sonny Bono
Performed by J. Grant Albrecht and Kate Higgins
See more »

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User Reviews

Destroy all quality!!
15 February 2009 | by (United Kingdom) – See all my reviews

I was extremely excited when i heard that a third edition to the Destroy all Humans series was being released because i own all of them including Destroy all humans: Big Willy Unleased and i have enjoyed playing everyone of them, which makes me regret to say that this particular destroy all humans was a disappointment , i partly blame the propaganda but it was also too short for my liking, most games that are short have excellent graphics but the graphics in this game were very poor (appart from in vital cut scenes) for a next generation console. It took me only two days to complete all of the objective missions (the storyline missions) and an additional one to complete the rest. Considering that this game cost me £33.30 i expected more. I found it unsatisfying and by the end i was wondering why it was so poor but thankfully it is not all bad. The storyline is good and the areas are very large allowing many places to destroy and many brains to collect (thats about it). Overall a lower standard than expected and too short!!!

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