Colonel Sergei Vladimir was a high ranking executive of the Umbrella Corporation, highly recognized as the company's Captain of the Guard, and Ozwell E. Spencer's most loyal officer.
Sergei Vladimir was an officer in Umbrella's Paramilitary service. During his army days, he held the rank of colonel and was still referred to by the rank over ten years after. His right eye was left blind after an accident in battle. With the sanctuary of the Soviet Union destroyed, Russia robbed of its former glory, Sergei was kindly given a most powerful position by Spencer, whom he received his orders from directly. The two would become close friends and Sergei would adapt a strong loyalty to Spencer in eternal gratitude, making sure that any of his superior's wishes, even the most radical, were carried out by any means necessary. He was involved in Tyrant research, and his experience in military affairs had made him instrumental in the founding of Umbrellas private militia, the Umbrella Biohazard Countermeasure Service.
During his time at Umbrella, Sergei grew a heated rivalry with another close employee of Spencer, Albert Wesker. Wesker seemed to have ulterior motives and grew suspicious of Spencer's intentions as well. Sergei believed that Wesker could not be trusted and would inevitably betray the company and its leader. Both men were always at each other's throats, and as Wesker's superior, Sergei was often displeased to find Wesker not obeying orders to the letter and would never hesitate to punish him for failure or remind him who was in charge. Wesker did not seem to be daunted by Sergei's threats, but the two men held a mutual respect for one another regardless and kept a close eye on one another.
As one of the rare individuals whose genetic make-up was capable of producing a Tyrant, Sergei became the genetic model for the majority of Umbrella's later Tyrant program, beyond the T-001 and T-002 projects initiated by the team led by Albert Wesker and William Birkin. Sergei also ordered the re-engineering of two T-103 Tyrants in order to produce his personal bodyguards, known as "Ivan". The 10 clones of Sergei would later form the basis of the T-103 model, which shaped every Umbrella manufactured Tyrant model thereafter. The mass production of T-103's which was spearheaded on Sheena Island was based on the initial Sergei clones, whilst T-103's implanted with the NE- Parasite became Nemesis T-Type.
Vladimir was also very involved in science works, and the Tyrant project. Although not as scientifically skilled as other noted scientists such as Alexia and Alexander Ashford, he was incredibly intelligent, and his masterpiece Tyrant was undoubtedly T-A.L.O.S., which he lead the creation of. He continually aided the production of his Ivans, mostly by contributing DNA and testing psychological variables he could create from the original, T-103 line.
U.M.F.-013 and the Red Queen
At the Umbrella Corporation Management Training facility, Sergei ordered one of his Ivans' to "punish" Wesker for his failure to bring the facility up and running. Wesker barely escaped with his life, with only the destruction of the facility giving him a chance to escape. Afterwards, Sergei and his bodyguard went to the Arklay Mountains Spencer estate. Rebecca Chambers quietly watched him exit the mansion alongside the Ivan carrying the T-A.L.O.S. prototype. They were attacked by a group of Cerberus's, the Ivan easily dispatching them. Sergei was then sent to Raccoon City to retreive the U.M.F.-013 computer core, which Sergei had loaded all of Umbrella's data onto. The helicopter also transported an Unnamed Umbrella Officer on board, who thought Sergei was reckless for stealing the core from the company, despite the fact that it was at Spencer's orders. Sergei, being "unstable" for this move in the employee's eyes, took the remark as a joke and pointed out how none of history's heroes are stable in their actions. Sergei also acknowledged how the core's data would allow Umbrella to rise from the ashes of defeat. Ada Wong managed to hitch a ride on the computer core as it was towed away below the copter, going unnoticed by Sergei. The missile launched by the government destroyed Raccoon City the next moment, passing merely feet away from the helicopter as Sergei watched.
Sergei saw himself going down in history as a hero because of the last task Ozwell E. Spencer had left him with. After Raccoon City's destruction, the government got suspicious of Umbrella and it's position in the world was dwindling, making it a sinking ship and no longer a sanctuary for his plans. Spencer had no choice but to futher distance himself from the public eye, which he had never stayed close to in the first place. However, before going into hiding, Spencer needed someone to take charge of what was left of his corporation. He chose Sergei, his most faithful and loyal subordinate, confident he would be able to uphold the seemingly doomed company. Sergei was named the chief executive officer of Umbrella some time between 1998 and 2003. It is likely the two still maintained contact behind the scenes. As his first decree as Umbrella's leader, Sergei moved all company data and assets to the Caucasus facility disguised as an oil refinery.
Wesker himself infiltrated the base at the same time a Biohazard wiped out some 98% of the research staff. Wesker managed to take a train to the main shaft where he met Sergei a second time. This time, Sergei sent both of his Ivans to kill him. An attack team lead by Chris Redfield and Jill Valentine entered the base, with the intention of destroying Umbrella for good. None of that would have been possible if not for Wesker's actions. Sergei stood in the way of Wesker's attempt to steal the U.M.F.-013's data and, after releasing the T-A.L.O.S. to fight Chris and Jill, he mutated into a huge Tyrant (indication that he infected himself moments before Wesker caught him). During the fight, Sergei seemed to enjoy the blows of pain Wesker issued to his weak point, evidencing a loose of sanity. Despite Sergei's immense strength, agility and organic weaponry, Wesker destroyed him, putting an end to his delusions that Umbrella and the Tyrants, his "brothers", would usher in a new era for mankind. The company's final leader defeated, Wesker stole all of the data, compressed into one disc, and shut down the Red Queen. The base was decomissioned and all data was erased in the process, ending Sergei's plans and sealing Umbrella's fate.