The Ghost Rider's skull has been redesigned for this sequel. The new skull appears to be black and charred, indicating that the skull is actually on fire as opposed to the clean fleshless skull simply cloaked in fire in the previous film.
Christopher Lambert was required to wear makeup that depicted heavy tattoos covering his entire head. It took so long to take off that he decided to keep it on when he returned to his hotel each night, until his filming schedule was complete.
There are two references to Vlad the Impaler, one of the devil's personas and on the side of the tow truck. Vlad inspired the book "Dracula" and subsequently the Marvel Comics supervillain, who is often a foe to Ghost Rider.
(at around 50 mins) When Moreau rides his motorcycle along the truck Nadya is driving down the road, the logo at the door of the truck reads "VLAD'S RECOVERY". A clear reference do Prince Vlad III of Wallachia, a.k.a. Count Dracula, by Bram Stoker's work.
Mark Neveldine, Brian Taylor:
In the sequence where Johnny Blaze (Nicolas Cage) is explaining the deal with the devil the film's directors are pictured shaking hands, while one of them is on fire. This mirroring the cover to 'Pink Floyd''s album "Wish You Were Here."
The trivia item below may give away important plot points.
While Carrigan is driving the ambulance and testing his new powers of decay, one of the items he picks up is a Twinkie. Nothing happens to it, thus bringing to mind the urban legend that Twinkies last forever or simply that plastic wrappers do not decay.