 | Joe Buck | ... | Himself - Play-by-Play Announcer |
| Tim McCarver | ... | Himself - Color Commentator |
| Ken Rosenthal | ... | Himself - Field Reporter |
| Jose Mota | ... | Himself - Field Reporter |
| Eric Byrnes | ... | Himself - Field Reporter |
| Jeanne Zelasko | ... | Herself - Pregame Host |
| Kevin Kennedy | ... | Himself - Pregame Analyst |
| Eric Karros | ... | Himself - Pregame Analyst |
| rest of cast listed alphabetically: |
| Josh Beckett | ... | Himself - AL Pitcher, Boston Red Sox |
| Carlos Beltran | ... | Himself - NL Starting Center Fielder, New York Mets |
| Bruce Bochy | ... | Himself - NL Coach, San Francisco Giants |
| Barry Bonds | ... | Himself - NL Starting Left Fielder, San Francisco Giants |
| Miguel Cabrera | ... | Himself - NL Third Baseman, Florida Marlins |
| Francisco Cordero | ... | Himself - NL Relief Pitcher, Milwaukee Brewers |
| Carl Crawford | ... | Himself - AL Left Fielder, Tampa Bay Devil Rays |
| Prince Fielder | ... | Himself - NL Starting First Baseman, Milwaukee Brewers |
| Brian Fuentes | ... | Himself - NL Relief Pitcher, Colorado Rockies |
| Ron Gardenhire | ... | Himself - AL Coach, Minnesota Twins |
| Ken Griffey Jr. | ... | Himself - NL Starting Right Fielder, Cincinnati Reds |
| Vladimir Guerrero | ... | Himself - AL Starting Right Fielder, Los Angeles Angels of Anaheim |
| Carlos Guillen | ... | Himself - AL Shortstop - Detroit Tigers |
| Cole Hamels | ... | Himself - NL Pitcher, Philadelphia Phillies |
| J.J. Hardy | ... | Himself - NL Shortstop, Milwaukee Brewers |
| Danny Haren | ... | Himself - AL Starting Pitcher, Oakland Athletics |
| Trevor Hoffman | ... | Himself - NL Relief Pitcher, San Diego Padres |
| Matt Holliday | ... | Himself - NL Left Fielder, Colorado Rockies |
| Orlando Hudson | ... | Himself - NL Second Baseman, Arizona Diamondbacks |
| Torii Hunter | ... | Himself - AL Center Fielder, Minnesota Twins |
| Chris Isaak | ... | Himself - National Anthem performer |
| Bobby Jenks | ... | Himself - AL Relief Pitcher, Chicago White Sox |
| Derek Jeter | ... | Himself - AL Starting Shortstop, New York Yankees |
| Kenney Dale Johnson | ... | Himself - National Anthem performer |
| Al Kaline | ... | Himself - AL Honorary Captain |
| John Lackey | ... | Himself - AL Pitcher, Los Angeles Angels of Anaheim |
| Tony LaRussa | ... | Himself - NL Manager, St. Louis Cardinals |
| Carlos Lee | ... | Himself - NL Left Fielder, Milwaukee Brewers |
| Derrek Lee | ... | Himself - NL First Baseman, Chicago Cubs |
| Jim Leyland | ... | Himself - AL Manager, Detroit Tigers |
| Mike Lowell | ... | Himself - AL Third Baseman, Boston Red Sox |
| Victor Martinez | ... | Himself - AL Catcher, Cleveland Indians |
| Russell Martin | ... | Himself - NL Starting Catcher, Los Angeles Dodgers |
| Willie Mays | ... | Himself - Ceremonial 1st Pitch / NL Honorary Captain |
| Brian McCann | ... | Himself - NL Catcher, Atlanta Braves |
| Gil Meche | ... | Himself - AL Pitcher, Kansas City Royals |
| Justin Morneau | ... | Himself - AL First Baseman, Minnesota Twins |
| Hideki Okajima | ... | Himself - AL Relief Pitcher, Boston Red Sox |
| Magglio Ordóñez | ... | Himself - AL Starting Left Fielder, Detroit Tigers |
| David Ortiz | ... | Himself - AL Starting First Baseman, Boston Red Sox |
| Roy Oswalt | ... | Himself - NL Pitcher, Houston Astros |
| Jonathan Papelbon | ... | Himself - AL Relief Pitcher, Boston Red Sox |
| Jake Peavy | ... | Himself - NL Starting Pitcher, San Diego Padres |
| Bradley Wayne Penny | ... | Himself - NL Pitcher, Los Angeles Dodgers |
| Placido Polanco | ... | Himself - AL Starting Second Baseman, Detroit Tigers |
| Jorge Posada | ... | Himself - AL Catcher, New York Yankees |
| Albert Pujols | ... | Himself - NL First Baseman, St. Louis Cardinals |
| J.J. Putz | ... | Himself - AL Relief Pitcher, Seattle Mariners |
| Manny Ramirez | ... | Himself - AL Left Fielder, Boston Red Sox |
| Willie Randolph | ... | Himself - NL Coach, New York Mets |
| Jose Reyes | ... | Himself - NL Starting Shortstop, New York Mets |
| Alex Rios | ... | Himself - AL Left Fielder, Toronto Blue Jays |
| Brian Roberts | ... | Himself - AL Second Baseman, Baltimore Orioles |
| Alex Rodríguez | ... | Himself - AL Starting Third Baseman, New York Yankees |
| Francisco Rodríguez | ... | Himself - AL Relief Pitcher, Los Angeles Angels of Anaheim |
| Ivan Rodriguez | ... | Himself - AL Starting Catcher, Detroit Tigers |
| Aaron Rowand | ... | Himself - NL Center Fielder, Philadelphia Phillies |
| C.C. Sabathia | ... | Himself - AL Pitcher, Cleveland Indians |
| Takashi Saitô | ... | Himself - NL Relief Pitcher, Los Angeles Dodgers |
| Freddy Sanchez | ... | Himself - NL Second Baseman, Pittsburgh Pirates |
| Johan Santana | ... | Himself - AL Pitcher, Minnesota Twins |
| Ben Sheets | ... | Himself - NL Pitcher, Milwaukee Brewers |
| Carl Shimkin | ... | Himself |
| Grady Sizemore | ... | Himself - AL Center Fielder, Cleveland Indians |
| John Smoltz | ... | Himself - NL Relief Pitcher, Atlanta Braves |
| Alfonso Soriano | ... | Himself - NL Left Fielder, Washington Nationals |
| Ichiro Suzuki | ... | Himself - AL Starting Center Fielder, Seattle Mariners |
| Chase Utley | ... | Himself - NL Starting Second Baseman, Philadelphia Phillies |
| Jose Valverde | ... | Himself - NL Relief Pitcher, Arizona Diamondbacks |
| Justin Verlander | ... | Himself - AL Pitcher, Detroit Tigers |
| Billy Wagner | ... | Himself - NL Relief Pitcher, New York Mets |
| Ron Washington | ... | Himself - AL Coach, Texas Rangers |
| Brandon Webb | ... | Himself - NL Pitcher, Arizona Diamondbacks |
| David Wright | ... | Himself - NL Starting Third Baseman, New York Mets |
| Chris Young | ... | Himself - NL Pitcher, San Diego Padres |
| Dmitri Young | ... | Himself - NL First Baseman, Washington Nationals |
| Michael Young | ... | Himself - AL Shortstop - Texas Rangers |
