License plate on Lex's car reads "LEX LXX." LXX is the Roman Numeral used to refer to the Septuagint, the first Greek version of the Bible, legendarily translated by seventy two writers in only seventy two days.
Lois compares Lana to Joan Jett the female punk rocker due to her all black outfit and hair. Joan Jett had a penchant for wearing all black and had black hair in the early 1980s. Lois and Chloe also sang "I Love Rock and Roll" by Joan Jett in Pariah.
Lionel and Lex both give Biblical allusions. Lionel warns Clark with the story of Samson and Delilah, in which Samson trusted his lover Delilah with the secret to his immense strength, only to have her betray him. Lex compares himself to the Apostle Paul, who became a changed man after being struck blind by lightning (though blinded by a bright light - revealed to be Jesus, according to the official account) while on the road to Damascus.
Lana absorbs Clark's powers and becomes a super-woman. In Superman comics, Lois Lane has, in several occasions, temporarily received Superman's powers and assumed the alter ego of Superwoman afterwards, most notably in Grant Morisson's "All-Star Superman". Superman's powers were also transfered to Lois in "Lois & Clark: The New Adventures of Superman (#3.7)" (1995) , where she becomes the Ultrawoman.
Brainiac appears as black liquid. This is the first time he appears in any form since Fallout, where he appeared as the Black box and was turned to ash. He is shown to be immune to kryptonite in earlier appearances, but in this episode it seems to affect this portion of him.
Chloe compares Lana to "La Femme Nikita" a French vigilante spy heroine from the movie and television series, and contrasts her to Florence Nightingale, who is considered the pioneer of modern nursing.
Lois says that the vengeful look in Lana's eyes "made Medea look like Mother Hubbard", a reference to Medea from Greek mythology and a play by Euripedes. Fueled by jealousy, Medea sought revenge on her unfaithful husband Jason. In contrast, Mother Hubbard is a kind, grandmotherly figure from a popular nursery rhyme.