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Genetic engineers Clive Nicoli and Elsa Kast hope to achieve fame by successfully splicing together the DNA of different animals to create new hybrid animals for medical use.



(screenplay), (screenplay) | 3 more credits »
2,642 ( 52)
4 wins & 23 nominations. See more awards »



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Complete credited cast:
Dren (as Delphine Chaneac)
Simona Maicanescu ...
Joan Chorot
William Barlow


Two young rebellious scientists are told by their employers to halt groundbreaking work that has seen them produce new creatures with medical benefits by splicing together multiple organisms' DNA. They decide to secretly continue their work, but this time splicing in human DNA. Written by Anonymous

Plot Summary | Plot Synopsis


She's Not Human ... Not Entirely. See more »


Drama | Horror | Sci-Fi

Motion Picture Rating (MPAA)

Rated R for disturbing elements including strong sexuality, nudity, sci-fi violence and language | See all certifications »

Parents Guide:




| |



Release Date:

4 June 2010 (USA)  »

Also Known As:

Hibrid  »

Filming Locations:


Box Office


$26,000,000 (estimated)

Opening Weekend:

$7,385,277 (USA) (4 June 2010)


$16,999,046 (USA) (30 July 2010)

Company Credits

Show detailed on  »

Technical Specs


Sound Mix:

| |


Aspect Ratio:

1.85 : 1
See  »

Did You Know?


The gestation cell that Clive and Elsa use to splice Dren has the acronym BETI placed conspicuously on the front of the machine. BETI stands for Biomechanical Extroutero Thermal Incubator. However, interestingly the word "BETI" means daughter in Urdu and Hindi, spoken in large parts of Pakistan and India. See more »


When Elsa finds Clive and Dren in the barn, she stands in the wide-open door. In the next shot, from outside, Elsa throws the barn door open and runs out. See more »


[techno music playing]
Clive Nicoli: This retarded, fascist, über music is the fuckin' problem. It's got us thinking in circles.
[turns on jazz music]
See more »

Crazy Credits

The company logos appear on X-rays. See more »


Referenced in The Tonight Show with Jay Leno: Episode #21.90 (2013) See more »


The 26 Letters
Written by Joyce Fitt
Performed by John Sheard
Courtesy of MJMC Productions
See more »

Frequently Asked Questions

See more (Spoiler Alert!) »

User Reviews

Playing of God
9 April 2011 | by (Rio de Janeiro, Brazil) – See all my reviews

Clive Nicoli (Adrien Brody) and Elsa Kast (Sarah Polley) are scientists of the Newstead Pharmaceutics researching the splice of DNA from different animals to form new genetic beings and find medical benefits to mankind. They have just created the hybrid Ginger and Fred and now they intend to join together human DNA to alter the genetic structure of their experiment. When the senior management calls off their experiment, they decide to secretly proceed and they generate a life form with human characteristics. They call it Dren (Delphine Chaneac) and Elsa is very fond of their creation that grows up fast and showing intelligence. When the company shutdown their experiment, they bring Dren to Elsa's abandoned farm and the scientists raise Dren like a daughter. But when it reaches adulthood, the sex drive of Dren is activated and Clive and Elsa learn that they have a serious problem to resolve.

"Splice" is a dramatic sci-fi horror film with the story of two young unethical scientists that decide to play God. The plot is unoriginal but is attractive and engaging, specially because the trio formed by Sarah Polley, Adrian Brody and Delphine Chanéac. The childhood trauma of Elsa is absolutely out of the context and a diversion to the mainstream. The special effects and make-up are awesome, transforming the gorgeous French actress Delphine Chanéac in a creature with an exotic beauty. My vote is seven.

Title (Brazil): "Splice – A Nova Espécie" ("Splice – The New Specie")

29 of 40 people found this review helpful.  Was this review helpful to you?

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