- The way Megamind's parents put him in a capsule to Earth just before his planet is destroyed
- The love interest is a reporter
- Hal's "space dad" is modeled after Marlon Brando as Superman (1978)'s father in Richard Donner's film version
- Almost all of Metro Man's super powers are the same as Superman's
- Megamind's pronunciation of Metro City has the same stress pattern as 'Metropolis' in Superman
- Megamind takes on a bespectacled secret identity similar to Clark Kent.
- In the Metro Man Museum, there's a statue of Metro Man preparing to catch an airplane. This is a reference to John Byrne's 'Superman' comics, where Superman made his first appearance by catching a plane and saving Lois Lane.