Scarlett Johansson, Bradley Cooper, Jennifer Connelly, and Ben Affleck have all appeared in a superhero movie. Johansson played Black Widow in Iron Man 2 (2010), Marvel's The Avengers (2012), Captain America: The Winter Solider (2014), Avengers: Age of Ultron (2015), Captain America: Civil War (2016), and Avengers: Infinity War - Part I (2018). Cooper played Rocket Raccoon in Guardians of The Galaxy (2014), Guardians of The Galaxy 2 (2017), and is rumored to be in Avengers: Infinity War - Part I (2018). Jennifer Connelly played Betty Ross in Hulk (2003). Ben Affleck played Daredevil in the self-titled movie (2003), and also Bruce Wayne/Batman in Batman v. Superman: Dawn of Justice (2016), The Justice League Part One (2017), The Justice League Part Two (2019), and is rumored to be in a solo Batman movie (2019).
Sasha Alexander plays Jennifer Aniston's sister in the film. She also guest starred in an episode of "Friends" during season 8. Alexander also starred in season 4 of "Dawson's Creek," one year before Busy Phillips joined the cast.