During the opening montage showing the development of the surrogates, there is a shot of an Asian man with an android twin. This is actually footage of Dr. Hiroshi Ishiguro of Osaka University and his creation - Geminoid, a prototype android double of himself.
A close-up shot of Strickland's FBI file shows his date of birth as 21 December, 1969 and birthplace as Lynn, Massachusetts. These are also the real date of birth and birthplace of actor Jack Noseworthy who plays Strickland in the film.
The VSI building was depicted by using a digitally altered version of the Dallas Bank of America Plaza (informally known as "The Green Building"). The interior of the building is actually in Cambridge, MA and is home to Genzyme and Momenta Pharmaceuticals. It was designed by Steven Ehrlich Architects & SMMA.
The unusual shoulder patch worn by Colonel Brendon is the 26th Infantry Division. A former division of the Massachusetts Army National Guard, it has been deactivated since 1993. The insignia is actually a stylized "YD", for their nickname, "The Yankee Division".
The trivia item below may give away important plot points.
During the opening scene when Canter and his father are discussing Tosca, Canter Jr. says "Don't tell me how it ends" and Canter Sr. responds "Like they all do - everybody dies" foreshadowing his plan.