The "To be continued . . . " ending parodies The Best of Both Worlds: Part 1 (1990), complete with identical titling and similar dramatic music. Patrick Stewart, who has a cameo in the follow-up episode Lois Kills Stewie (2007), played Captain Picard in it.
This episode and the following episode, with the title names reversed (Stewie Kills Lois (ep 6.4) and Lois Kills Stewie (ep 6.5)), were originally broadcast back-to-back on November 4, 2007 as a 2-parter.
In this episode, Quagmire compares Peter to killer Bernie Goetz. In actuality Bernie Goetz shot 4 teens in 1984 on a subway car, paralyzing one of them, but has never killed anyone.
During the Beatles Cut-away Of them says "oh that's great work Ringo. We'll put it over here in the refrigerator" Firstly they wouldn't have said "refrigerator" thay would of said 'fridge' And secondly putting children's work on the fridge door is an American tradition which has only come over here within the last couple of decades. Just as British TV is more American than ever.
Although being aired in an evening time-slot this episode underwent heavy editing on German Television.