With Lois back in Quahog, Stewie escapes with Brian to Washington, D.C. and sets out to initiate his latest plan for world domination.


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Episode cast overview, first billed only:
Chris Griffin (voice)
Meg Griffin (voice)
Paula Abdul (voice)
Rupert (voice)
Katie Holmes / Hilary Swank (voice) (as Alex Breckenridge)
Simon Cowell (voice)
Mark Hentemann ...
Obie (voice)
Randy Jackson (voice)
Judge / Ollie Williams (voice)
Danny Smith ...
Rob Schneider (voice)
Avery Bullock (voice)
Tom Cruise (voice)


With Lois back in Quahog, Stewie escapes with Brian to Washington, D.C. and sets out to initiate his latest plan for world domination.

Plot Summary | Plot Synopsis


Animation | Comedy

Parents Guide:



Release Date:

4 November 2007 (USA)  »

Company Credits

Show detailed on  »

Technical Specs


Aspect Ratio:

1.33 : 1
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Did You Know?


When Lois is trying to shoot Stewie with the Gatling gun, the bullets hit paintings of Ronald Reagan and George Bush, then miss a painting of a naked Bill Clinton before hitting and then obliterating a painting of George W. Bush. See more »


Stewie sings that Bill O'Reilly's Dermatologist has made it onto his Little List. However, Stewie then kills Bill O'Reilly, not Bill O' Reilly's Dermatologist. See more »


[Peter has just killed Stewie]
Peter Griffin: It's just been revoked!
Brian Griffin: Uh, Peter, he didn't really set you up for that Lethal Weapon line. It... it doesn't really work here.
Peter Griffin: Oh. I'll have what she's having!
Brian Griffin: That's... better?
See more »


References Lethal Weapon 2 (1989) See more »


Afternoon Delight
Written by Bill Danoff
Performed by Starland Vocal Band
See more »

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User Reviews

Family Guy "Lois kill Stewie part.2"
10 December 2011 | by (United States) – See all my reviews

After Lois's odd return from the dead. Stewie decides goes rogue and decides to carry out his deed on world domination after tying up the griffins. After newly passed down laws go into action Lois is angered by Stewie's doings and decides to kill Stewie. This is an ending up result of a major shootout between Stewie and Lois. After Lois runs out of bullets Stewie gets the upper hand with a shotgun. Suddenly Peter appears and shoots Stewie down. After Peter brings Stewie's evil rain to an end it is revealed it was on a simulation presented by Stewie. After Brian enters the room him and Stewie indulge in an argument that it was a dream not a simulation. After the argument Stewie tells him it was better than the ending of the Soponos.

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