The film's release date was postponed three times. First, due to Bernie Mac's untimely death. The second time was for the death of John Travolta and Kelly Preston's son, Jett Travolta. The final time was because Robin Williams had a health scare that required surgery. All of the postponement ultimately caused the movie to be released more than a year after the original, intended release date, finally releasing on November 25, 2009.
Was originally supposed to be released theatrically in non-Quebec French-language markets as "Papy-Sitter" a wordplay with the French word "papy" meaning "grandpa". When Walt Disney Pictures decide to release the film straight-to-home-video in these markets due to the film's US financial failure, they instead went with the Quebec title "Les 2 Font La Père" which is a also a wordplay based on the French expression "les 2 font la paire", somewhat equivalent to "two of a kind" and the word "père" which means "father".
Majority of production, including most of Tokyo scenes (except for the Tokyo airport and Tokyo street scenes that were shot in New York City) were done in Connecticut, thanks to the 30% Film/TV production tax incentive that the State offered at that time. There was no overseas location shoot in this film.