Pete and Violet anxiously prepare for their wedding day, but Cooper may have to intervene when emotions and fear of the future run high. Things have taken a surprise turn with Addison and Sam, and Naomi juggles the burden of caring for her daughter and newborn granddaughter and worries about Dink's ability to parent. Despite disagreements and deeply-rooted conflicts, the doctors come together to mourn the loss of their friend, Dell.
Violet and Cooper make amendments to their friendship in order to please their significant others; Pete and Cooper get in an argument involving marijuana use by a patient (guest starring Justine Bateman as Sydney); Addison is conflicted about going public with her new romance, and Sheldon's decision to deny approval for a patient's sex change backfires.
The man responsible for endangering Maya's life and killing Dell shows up at Oceanside Wellness with a heart condition, and Sam struggles with his responsibility to help; contrary to Violet's warnings, Pete volunteers at a friend's home medical clinic and ultimately puts a patient's life at risk; and news of Addison's new romance doesn't go over well.
The arrival of Dell's young orphaned daughter, Betsey, stirs up the emotions of everyone in the practice; and Pete and Amelia disagree over a risky surgery to treat a woman who has been experiencing chronic and insufferable pain throughout her pregnancy.
Much to her displeasure, Addison is teamed with a new oncologist, Dr. Rodriguez, to treat a newborn baby with a malignant tumor; when Violet and Sheldon visit a prison in order to interview inmates who are up for parole, Pete is highly uncomfortable as Violet tries to help a parolee; and Addison and Violet suggest Sheldon could be the solution for Amelia's needs.
Addison and Sam's relationship is strained when they disagree over the treatment and safety of a comatose patient who has become pregnant, while Pete and Charlotte are faced with the ethical dilemma of revealing the HIV status of a patient who has been in a serious auto accident. Violet crosses some boundaries with Pete's family as she gets caught up in the fray of Lucas's first Halloween.
After Pete discovers Charlotte in the halls of the hospital bloodied and bruised, he and their fellow doctors come to her aid, but only Addison learns the truth from Charlotte that she was sexually assaulted.
Charlotte chooses to suffer in silence as she tries to deal with the emotional aftermath of the attack, as Addison struggles to keep the events of that night a secret, while Cooper and the doctors of Oceanside Wellness fight their own demons arising from the assault.
Despite how Charlotte is choosing to deal with the aftermath of her sexual assault, her fellow doctors think they know what's best, teaming up to pursue criminal charges against her attacker. Pete gets a surprise visitor, his estranged brother, who has come to ask Pete to help release their sick mother from prison.
When the District Attorney's office delivers bad news to Charlotte and Cooper about her sexual assault case, Cooper is outraged and Charlotte seems numb, as a case involving a pregnant drug addict hits hard with Addison, who wants a child of her own with Sam.
Addison's mother, Bizzy, aggressively demands her daughter do whatever it takes to save her partner from dying - including working with Dr. Rodriguez once again. Meanwhile Amelia and Pete's medical consultation is complicated when a patient's wife and his mistress disagree on the course of treatment, Charlotte and Cooper try to be intimate with each other again, and Violet considers publishing a personally-revealing book she's written.
Addison plans Bizzy and Susan's wedding while trying to keep her distance from the overly flirtatious Dr. Rodriquez. Sam is concerned about the care his longtime patient is receiving, and Sheldon refers Charlotte to his mentor and friend for psychiatric help.
Charlotte's attacker, Lee McHenry, arrives at St. Ambrose Hospital, injured by his girlfriend and in need of urgent care, and Sam and Charlotte must decide whether or not to save his life. Meanwhile, Susan's health takes a turn for the worse, and Addison's mother, Bizzy, begs her daughter to do everything in her power to help.
After tragedy strikes the Montgomery family, Addison goes home to Connecticut and Sam and her friends decide to join her. Meanwhile, Sheldon and Violet clash when Sheldon's death row patient confesses to a crime that his wife, one of Violet's patients, believes he didn't commit.
Charlotte and Cooper look to forgive each other after revealing secrets during couples therapy, Violet seeks the forgiveness and approval of her fellow doctors after they learn her novel-in-progress will make all of their personal lives public, Sheldon treats a patient who claims to have multiple personality disorder, and Sam and Naomi team up on a case involving a pregnant teen with Down's Syndrome.
The doctors of Oceanside clash when an expectant mother and her husband, desperate to have children, come to them in order to harvest the eggs of their unborn, ill-fated baby; meanwhile, Amelia tries to help a friend who threatens suicide if her tests for Huntington's Disease are positive, and Fife returns to tell Naomi how he feels about her.
At the launch party for Violet's book, Sheldon falls for the smart, beautiful Dr. Marla Tomkins, even though she's the critic who panned Violet's tome; meanwhile, Addison's and Pete's patient is caught in a love triangle with her brother-in-law and sister, for whom she is a surrogate, and Cooper and Sam try to convince a family to make their son's health a priority over his successful wrestling career.
When Pete's brother, Adam (Kyle Secor), brings their sick mother (Louise Fletcher) for a consult, Pete discovers her illness may be his brother's fault. Meanwhile, in the wake of her book's success, Violets walks in on Sheldon just as he's about to take her archenemy on a date, and Cooper treats a young musical prodigy whose brain tumor could prevent him from ever playing the piano again
The doctors of Oceanside Wellness are faced with a tough decision -- to point out all areas of vulnerability within the practice and risk the termination of some of their own, or to dissolve the practice and each go their separate way. Addison has a new admirer in town who offers her a very tempting proposition. Meanwhile, Charlotte is assigned to a case that hits very close to home.