Sanctuary was the first television series in North America to start production using the new RED camera exclusively, capturing images at four times the resolution of a high definition camera. It's also the first web series to become a full-season television series, one of the only television series to shoot extensively on green screen with virtual sets.
Christopher Heyerdahl tried, with cooperation of the crew, to hide the fact, that he was playing Bigfoot character. In the first season Bigfoot is credited as Himself. He was very upset the day that the secret leaked out of the set, after one of the visitors saw him halfway through the make-up process.
The Sanctuary Poster is a composite image consisting of the central business district in Perth, Western Australia and CGI graphics. The tallest building in the poster is the Central Park tower. The orange building in the poster is Chancery House.