Due to disturbing behavior throughout - including violence, gruesome images, strong sexual content - the first theatrical trailer of the movie was digitally altered. It showed operation scenes without human organs, also Milo Ventimiglia's hands digitally erased in a love scene. But the later Red Band version was released without any alterations.See also Into the Blue (2005) and The Hangover (2009).
Actress Lauren Lee Smith (Juliette) and actor Johnny Whitworth (Griffin) were bothe regulars on CSI for a while. Lauren Lee Smith on CSI and Johnny Whitworth on CSI: Miami. Johnny's character name on CSI: Miami was Jake, and Michael Weston's character name in this movie is also Jake.