The comedian's film The Love Guru dominated the 29th annual event, taking home Razzies for worst picture, screenplay and actor on Saturday - a day before the Academy Awards celebrates Tinseltown's finest.
Paris Hilton scored a triple dishonour, winning awards for worst actress for her part in The Hottie and the Nottie and worst supporting actress for her cameo in Repo! The Genetic Opera.
Hilton was also included in the worst screen couple alongside her Hottie co-stars, Christine Lakin and Joel David Moore.
Neither the heiress nor funnyman Myers were present to collect their gold spray-painted Raspberry statuettes.
Pierce Brosnan was named worst supporting actor for his singing turn in Mamma Mia!, while the worst-director Razzie went to Uwe Boll for his three films In the Name of the King: A Dungeon Siege Tale, 1968 Tunnel Rats, and Postal.