When the doctor at the start of the film is looking at the zombies, he says "behold a pale horse". This is a line from the book of the Revelation, also spoken in the Johnny Cash song "The Man Comes Around", which is used at the start of another zombie film, Dawn of the Dead (2004).
The story was allegedly inspired by Eugène Ionesco's allegorical play "Rhinoceros", in which citizens of a small French village inexplicably turn into the titular animals one by one. As a nod to this literary source, Robert Englund's character is named "Ian Essko".
Los Angeles-based recording artist Roxy Saint (Lillith) also provided several of the songs on the film's soundtrack, including "Don't Kill the Star", "Bad Guy", and most noticeably, "Smother You", which is used during Jenna Jameson's (Kat's) first post-death strip scene, and over the end credits of the movie.