The names of the last two lycanthrope victims, "Mina" and "Heather Bram" are an allusion to the classic horror novel, 'Dracula'. Bram Stoker was the author of the novel and Mina was Dracula's last victim.
This episode is partially based on the Dresden Files book, Fool Moon.
This episodes guest actors were also on Republic of Doyle. Krista Bridges played Kathleen Doyle, Matt Gordon did 2 episodes as Fat Ronnie, and Kathleen Monroe also did 2 episodes as Annabelle.
When Murphy is called back, because the FBI are about to take over the case, an building entrance is shown - 'Chicago Police, District 27'. There is no District 27.