A fly interrupted the show on two occasions by landing in one of the guests' drinks. In June 2013, the diving fly made Steve Carell go off-topic when it landed in Chris O'Dowd's alcoholic beverage. In October 2014, Emma Thompson interrupted the conversation in order to fish a fly out of Luke Evans's glass of red wine.
In 2014, after 238 episodes, Graham Norton's chair fell apart while he was interviewing Nicole Kidman, Julie Walters and Hugh Bonneville. The chair was swiftly replaced with a new one that had a more dowdy design. Kidman and Walters said that in the new chair, "He [Graham Norton] looked like he was in the doctor's waiting room."
Few major names have originally been scheduled to appear on the show, but later withdrew. In 2014, Nicole Kidman withdrew due to illness, in 2013, Jay Z canceled due to scheduling conflicts, and in 2007, Hilary Swank refused to appear on the show, after she discovered "the nature of the show."
Both Daniel Radcliffe and David Tennant visited the show while growing hair to a great length for a part. In both times, Graham Norton commented on the hair as the first thing when they arrived on the couch, and described it as "silly."
Carrie Fisher's final talk-show appearance, as she passed away three weeks after the final interview in December 2016. She appeared on the show twice and was one of the few guests to previously have appeared on Graham Norton's other talk show So Graham Norton (1998).
In Series 19, Graham Norton paid tribute to Ronnie Corbett, who had passed away on March 31, 2016 and had made three appearances on his talk show. He credits Corbett with the Red Chair segments as they were inspired by Corbett's armchair monologues in the long running _The Two Ronnies (1971)_ sketch comedy show, which ended in 1987.
A trio of almost three "Doctor Who's" were assembled once on the couch. In 2013, Matt Smith and David Tennant appeared opposite Robbie Williams. In 2004, when "Doctor Who" was announced to return, Williams was rumored to play The Doctor in the revived series. Later, Tennant would perform the tenth Doctor and Smith was the eleventh Doctor.
The episode dated 22 April 2016 ends with a tribute to popular British comedian Victoria Wood, who died aged 62 two days before the show's broadcast. A clip of Wood's appearance in December 2014 was shown.
In (#18.12) Carrie Fisher, Daisy Ridley and John Boyega appeared on this show to promote Star Wars: Episode 7 - The Force Awakens (2015), and was joined by Kylie Minogue and David Beckham. Fisher starred in a Australian science fiction film titled The Time Guardian (1987), which was released exactly a decade after the very first "Star Wars" film.