The fight scene between Saul (James Franco) and Carol (Rosie Perez) was, for the most part, improvised. Because of this, Franco was worried that he would hurt Perez, and would ask her for permission to do certain things during the fight. In the end, Perez actually did get hurt, and got a bruise after Franco accidentally bit her too hard on the thigh, but Perez didn't tell him until after filming was done, so he wouldn't feel bad.
As he is handing Dale some guns, Red (Danny McBride) says, "Ted Jones messed with the wrong melon farmers." This is a reference to the common network television practice of dubbing over swear words with less objectionable words, or terms that have a similar sound and length - even if the replacement words don't really make sense in the context of the movie. "Melon Farmers" is used most famously as the dub for "Mother F***ers" in the network television version of the Die Hard film franchise (in which lead character John McClane's famous catchphrase, "Yippie-kai-yay, Mother F***er!," became "Yippie-kai-yay, Melon Farmer!").
When James Franco smashes the bong over Danny McBride's head, it was supposed to be a fake, breakaway bong, so McBride could take part in the stunt. However, it was filled with some water, and when Franco actually smashed it, McBride was mildly hurt.
Seth Rogen told the April 25 issue of Rolling Stone Magazine, that the filmmakers originally wanted a budget of fifty million dollars, but was only able to secure twenty-five million dollars, due to the drug-heavy subject matter.
During a July 2008 interview with the Orange County Register about this movie, the interviewer told Seth Rogen and James Franco that he prepared for the interview by watching the classic stoner comedy Fast Times at Ridgemont High (1982) the night before. When he asked Rogen and Franco if they prepared likewise before making this film, Franco said he prepared by making out with Spicoli (a reference to his having shot Milk (2008), in which he and Sean Penn play lovers).
The first time Dale visits Saul, he apologizes for coming up before being buzzed in, to which Saul replies, "Stuff your sorries in a sack, man!" This is actually from an episode of Seinfeld (1989), where the characters disagree over whether or not the quote is a commonly used expression. Ironically, after the popular episode aired, and was replayed over and over in syndication, "Stuff your sorries in a sack", actually did become a casually and commonly used expression, as seen here in this film.
The place where Saul and Dale are held hostage, is where the beginning of the movie takes place underground. In the back of the room, you can see the water suit, in which the people used, when testing the effects of marijuana.
James Franco had stated in an interview with MTV news and Judd Apatow stated the same at a Comic Con event that they were considering making a movie sequel that would intersect the story lines of this movie and Superbad (2007) but this never materialized.
Saul (James Franco) carries a Taconic High School duffle bag in almost every scene of the movie. Taconic High School is a public school in Pittsfield, Massachusetts. The school's mascots are "The Braves", and the colors are green and yellow.
Trifecta doesn't actually mean anything related to the special T-shaped joint or the smoke inhaled. It means "a bet which is won by correctly selecting in the correct order the first three finishers in a race."
In the original script, Dale's girlfriend Angie was an adult and a strong mature businesswoman in sharp contrast to her slacker boyfriend. The decision to rewrite Angie as a high school senior was done to avoid unfair comparisons with Shaun of the Dead (2004).