After Leonard tries to help Penny following a failed role on a TV show, she makes an important decision. Meanwhile, Raj and Stuart try to practice their social skills, and Sheldon navigates the intricacies of being funny.
Sheldon tries to relax after he is forced to take a vacation. Leonard struggles to be supportive of Penny after she quits her job. Amy receives unwanted attention from a co-worker. Bernadette seeks Stuart's help in replacing one of Howard's comic books.
Leonard's purchase of a dining room table causes Sheldon to reevaluate the changes in his life. Meanwhile, Howard is offered a chance to go back to space and Bernadette struggles with whether or not to encourage him.
After arguing with Sheldon, Howard tries to make amends by taking him to NASA headquarters in Houston. Penny has second thoughts about quitting her waitressing job when her car dies. Amy gets involved in trying to find Raj a date.
While Raj is wracked with guilt when he tries to date Lucy and Emily at the same time, Penny wrestles with whether to take a role in a cheesy movie and Sheldon is torn trying to choose between two gaming systems.
Penny gets fired from her movie and takes a serious look at her life. Raj sees Emily on a date with another man at the movies. Howard and Bernadette have to take care of his mother after she breaks her leg.
Sheldon gets upset about his career, the destruction of the comic book store and Leonard and Penny's future living arrangements. Howard and Bernadette struggle to keep hold of a caregiver for Mrs. Wolowitz.
Leonard and Amy take an unexpected road trip to Arizona to pick up Sheldon. Meanwhile, Penny interviews for a job at Bernadette's company, and Howard is weirded out by Stuart's relationship with Mrs. Wolowitz.
Howard becomes nervous after NASA asks him to throw out the first pitch at a Los Angeles Angels game. Meanwhile, Leonard and Penny try to prove Sheldon wrong after he says that he and Amy are a 'superior couple'.
Amy and Bernadette accuse Penny of being a 'buzzkill' after she gets an email from work during their Vegas weekend. Meanwhile, the guys try to invent something cool, but only come up with new ways to procrastinate.
Sheldon and Raj test whether they could survive a dark-matter research expedition in a salt mine by simulating the conditions in a steam tunnel. Meanwhile, Leonard and Penny seek advice from Howard and Bernadette when they argue about money.