Leonard and Amy take an unexpected road trip to Arizona to pick up Sheldon. Meanwhile, Penny interviews for a job at Bernadette's company, and Howard is weirded out by Stuart's relationship with Mrs. Wolowitz.
The guys are stranded in the middle of nowhere when Leonard's car is stolen on the way to the Bakersfield Comic-Con. Back home, the girls try to figure out why the guys are so fascinated with comic books.
A date between Raj and Lucy takes both of them out of their comfort zones. After a trip to Las Vegas goes awry, the girls join in on a Dungeons & Dragons game, which causes Amy and Sheldon to reevaluate their relationship.
Howard tries to do something special to celebrate the anniversary of his first date with Bernadette. Sheldon is conflicted when he makes a major scientific breakthrough but some details have to be corrected.